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In a recent study a CMV DNA load
2020-12-14

In a recent study, a CMV DNA load cut-off of 500 IU/ml in BAL fluid was found to have a positive predictive value of ∼50% for the presence of probable CMV pneumonia (considering a prevalence of this event of 10% among patients at risk and undergoing BAL testing). Tan et al., in contrast, found CMV D
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The instructive precedent for galectin phosphorylation is hu
2020-12-14

The instructive precedent for galectin phosphorylation is human galectin-3 (hGal-3). Its serine modification by protein kinase CK1 in the N-terminal tail is relevant for nuclear export during the course of apoptosis regulation and contact formation with the neural cell adhesion molecule L1 , , , . T
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br In patients with type I diabetes mellitus
2020-12-14

In patients with type I diabetes mellitus poor management causes/INS; a drastic rise in glucose levels resulting in diabetic ketoacidosis (DKA). About 1% of DKA episodes can be complicated by cerebral edema. ET and its receptors are involved in the regulation of /INS;cerebral blood flow. We studie
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Diclofenac Many researchers studied the experimental investi
2020-12-14

Many researchers studied the experimental investigation of RHA in cement enhances the strength and durability of the concrete [9], [10], [11], [12]. It is most important that concrete must withstand its strength even after it is being exposed to any corrosive environment over a period of time. In ad
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Building s constructional elements should be able to protect
2020-12-14

Building's constructional elements should be able to protect residents from the negative effect of noise caused by surroundings [19]. The World Health Organization estimates that each year more than one million Healthy Life Years are lost in the European Union member states and other Western Europea
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Estrogen related receptors ERRs are orphan nuclear
2020-12-14

Estrogen-related receptors (ERRs) are orphan nuclear receptors and have three members including ERRα, ERRβ, and ERRγ (Yasumoto et al., 2007). Though they are termed as ERRs due to the sequence homology with estrogen receptors, they don’t need to bind estrogens to exert action. Generally, ERRs bind t
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br Acknowledgements Professor Olli A J nne is warmly thanked
2020-12-14

Acknowledgements Professor Olli A. Jänne is warmly thanked for support and for providing excellent research facilities. Professor Patrik Finne is acknowledged for his help with statistical analyses. Drs Ronald Evans, Vincent Giguère, Jorma Palvimo, Malcolm Parker, and Anastasia Kralli are acknowl
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In particular EphB has been one of the
2020-12-14

In particular, EphB4 has been one of the most studied receptor of the Eph family: inhibition of EphB4 expression using interfering-RNA or antisense oligonucleotides inhibited proliferation, survival and invasion of PC3 prostate cancer WP1066 australia in vitro and in vivo. Inhibition of EphB4 signal
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Several studies have shown that independently of body weight
2020-12-14

Several studies have shown that, independently of body-weight control, the central actions of leptin improve glycemic control in obese diabetic rat and mouse models [62]. For instance, restoration of OB-Rb expression in OB-Rb-deficient mice, and in particular in POMC neurons, was sufficient to norma
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Conventional aromatic radiofluorination via nucleophilic
2020-12-14

Conventional aromatic radiofluorination via nucleophilic substitution requires electron-withdrawing activating group(s) at the ortho or para position to achieve good radiolabeling yield. In the case of CJ-042794 (), the phenoxy substitution para to the fluoro group is considered an electro-donating
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There are conflicting studies on ET axis and its
2020-12-12

There are conflicting studies on ET axis and its relationship with clinicopathologic parameters in various cancers. Endothelin axis expression in the tissue and in blood has been associated with advanced cancer characteristics in colorectal, breast, and prostate cancer, while showing no linkage to c
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Exposure to ultraviolet radiation with sunlight is generally
2020-12-12

Exposure to ultraviolet radiation with sunlight is generally accepted as the major cause of basal-cell carcinoma (Gallagher et al., 1995). The risk of this disease is significantly increased by age. Skin cancers are the most common tumours of the head and neck region and their prevalence shows progr
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HCV has evolved mechanisms to evade humoral
2020-12-12

HCV has evolved mechanisms to evade humoral immune responses including high functional flexibility and variability of immunogenic portions of its envelope proteins. The highest sequence variability occurs in the first 27 Bryostatin 1 of the N-terminus of E2, which is referred to as the hypervariable
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Immunofluorescence assays were performed to localize the enz
2020-12-12

Immunofluorescence assays were performed to localize the enzyme during growth and differentiation to further characterize Giardia E1. As stated before, the assays showed that the microtubule generated recognized specific E1 forms (E1-114, E1-90 and E1-67 with anti-gNTE1; and E1-47 with anti-gE1CT);
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br Results br Discussion Many assays in
2020-12-12

Results Discussion Many assays in the literature for DBH require the use of catalase to protect the active site from hydrogen peroxide, which is a by-product in the initial step of the reaction. For the non-immobilized enzyme there was a visible increase in the rate with increasing amounts of
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